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Homeostasis: Cannabinoid, Progesterone and Nuclear Receptors

5/31/2017

Nuclear Receptor In Action

Think of a cell as a hub: a center of communication.

This hub has gates and points of entry: for our example, think of cannabinoid and progesterone receptors. These receptors facilitate communication with other hubs and inside a hub (with other cells and inside a cell).

There are nuclear receptors in all hubs/cells; these receptors regulate our genes (by transcribing DNA) and control our development, homeostasis and metabolism.

Recall that endometriosis is a disruption of a hub and its network: the cells grow (generate) as they are designed to do, just in the wrong spot.

An obvious point of disruption and research is the communication between progesterone and nuclear receptors; another is anandamide and all the other cannabinoids (endo, plant and pharmaceutical), as they too can modulate nuclear receptors.

We’ll begin with that homeostatic science next week: cannabinoids modulating nuclear receptors - and thus our every day.

*Next Up: Wednesday 7 June and a Homeostasis: If Not CB Three, then CB Third.

Posted by Bryan W. Brickner

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Homeostasis: Endometriosis, Progesterone and Cannabinoid Systems

5/24/2017

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Progesterone

Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

The above title was published in Fertility and Sterility in 2012 and can be found on PubMed.

The research finds that endometriosis, where cells grow outside instead of inside the uterus (endometrium), is caused by a failure to communicate between progesterone and the cannabinoid system; this failure is painful and contributes to infertility. Summary quote from the research: “Our studies reveal a role for the anti-inflammatory actions of progesterone in regulating endometrial cannabinoid signaling, which is disrupted in women with endometriosis.”

How does that work though? What is disrupted? If communication between progesterone and the CB1 receptor is disrupted (as cells grow, just in the wrong place), how do cells normally communicate in a healthy, undisrupted homeostatic way?

The answer involves cannabinoid and progesterone nuclear receptor signaling: let’s just begin there next week.

*Next Up: 31 May and a homeostatic view of Progesterone Nuclear Receptors and Cannabinoid Systems.

Posted by Bryan W. Brickner

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Life Serotonin Supplementation (LSS): Shivitti, Healing and Psychedelic Physiodelia

5/3/2017

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Shivitti: the eighth verse from the sixteenth Psalm,
“I have set the Lord always before me.”

Our example today for “psychedelic physiodelia” is from Shivitti: A Vision, the story of five journeys with LSD to heal Auschwitz nightmares.

A survivor of Auschwitz is living in Israel in the 1970s and hears of other sufferers of concentration camp symptoms finding relief at a clinic in Europe; the treatment uses injections of LSD to heal traumas.

Ka-Tzetnik 135633, Mr. De-Nur, the survivor and author, writes of his healing experiences that are based on the activation of his serotonin system via LSD.

De-Nur’s serotonin-induced visions are psychedelic in both meanings of the word; they happen in his mind and embrace his soul.

De-Nur’s serotonin-induced visions are physiodelia as well; the LSD-injected journey concludes when the doctor (guide) simply touches the patient’s arm – which ends the trip and creates space for healing.

De-Nur reported hearing the Creative Voice in a session and was able to heal his Auschwitz nightmares after five LSD treatments.

Shivitti: A Vision
Ka-Tzetnik 135633
Translated from the Hebrew by Eliyah Nike De-Nur and Lisa Herman (1989/98)

Press Release for Shivitti: A Review of Ka-Tzetnik 135633’s Vision
Bryan W. Brickner (2015)

*Next Up: 24 May with Progesterone and Cannabinoid Systems.

Posted by Bryan W. Brickner

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Homeostasis: Cannabinoid, Progesterone and Nuclear Receptors

Homeostasis: Endometriosis, Progesterone and Cannabinoid Systems

Life Serotonin Supplementation (LSS): Shivitti, Healing and Psychedelic Physiodelia

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