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Summer Union 2016: Johnny Reb and Gus Kotka Nowhere Moon Dark Side

7/30/2016

Johnny Reb and Gus Kotka Nowhere Moon

Part 6 of 13

On a piece of ground in your home town

“How’s this Gus?”
“Better.”
“The thirty Thousand -”
“Johnny,” interrupted Gus, “that 30,000 we've been kicking around.”
“Yes.”
“We had a census in 1860, just like the Constitution says.”
“We did.”
“And that census said we had over 30 million people.”
“True Yank.”
“So what happened?”

Johnny Reb and Gus Kotka Nowhere Dark

“What do you mean?”
“Well,” Gus offered, “30 million divided by 30,000 is kind of easy math.”
“It is.”
“So it ciphers to 1,000 federal districts.”
“Yes.”
“So that’s 1,000 federal Representatives in 1860.”
“True, but not real.”
“What’s that mean?”
“Usurpation.”
“Theft?”

Johnny Reb and Gus Kotka Nowhere Side

“Yes, in the form of stolen representation Gus: Congress stopped obeying the Constitution.”
“Couldn’t follow orders ‘eh?”
“You got it.”
“How many Reps were there in 1860 Johnny?”
“There were 241 Gus.”
“And four million slaves.”
“True.”
“So using the three fifths clause, slaves would have equaled 2.4 million free people.”
“Yes.”
“Which meant a bunch of Representatives representing slaves.”
“There would have been 80.”
“That’s a lot Johnny.”
“It caused the war Gus.”
“The issue of slavery?”
“The issue of constitutional representation of slaves …”

Next Up: Thursday 4 August and a 2020, Defining a Conservative-Liberal Via John Kass and Eric Zorn of the Chicago Tribune.

Posted by Bryan W. Brickner

2020: 7/20 Bill of Rights Participation Day, Do Due Diligence

7/19/2016

20 minutes for $20

Do due diligence.
If not now, when?
If not when, why?

Amendment VII

Next Up: The Union 2016 summer series continues on Sunday 31 July with part 6, Johnny Reb and Gus Kotka Nowhere Moon Dark Side.

Posted by Bryan W. Brickner

Summer Union 2016: Johnny Reb and Gus Kotka Nowhere Feather Birds

7/16/2016

Johnny Reb and Gus Kotka Nowhere Feather

Part 5 of 13

“Me sees Turkey feathers Reb.”
“Me too Yank.”
“You were right about feeling Morgan around.”
“Turkey and Snake.”
“Yes.”
“Mt Horeb take-me-back moment.”
“Me too Reb.”
“What’s next to the feathers?”
“Document looks like.”
“Let’s look closer.”
“Sure.”

Johnny Reb and Gus Kotka Nowhere Birds

“Constitution Gus.”
“We the People too.”
“The counter to Tory Crown.”
“Turkey feathers?”
“Written law Yank.”
“I thought you meant that.”
“Sure you did.”
“Who’s the caped avenger?”
“Let’s look.”
“Okay.”

Johnny Reb and Gus Kotka Nowhere Flocking

“I’m guessing General Washington Yank.”
“Me too Reb.”
“The caped avenger is pointing at something.”
“Into the breach perhaps.”
“Or the We in ‘We the People.’”
“Both work: what’s the script Reb?”
“The words from Article I.”
“Significant?”
“The thirty Thousand we’ve been jawin’ about is there.”
“Right there?”
“Right there before us.”
“Sign overload Johnny.”
“Agreed Gus.”

Next Up: Wednesday 20 July and a 2020: 7/20 Bill of Rights Participation Day, Do Due Diligence

Posted by Bryan W. Brickner

2020: Part Two of the 7/20 Bill of Rights Participation Day Preparations, Jesus and Caesar

7/14/2016

Amendment VII

Render unto Caesar the things that are Caesar’s,
And unto God the things that are God’s.

Give Caesar Caesar’s things, Jesus of Nazareth said.

The US Constitution is our modern metaphor for Caesar, temporal power.

When Caesar isn’t rendering (giving) what is the law, and instead diligently reigns via usurpation by ignoring the representation ratio, one Representative for every thirty Thousand people, and the 7th Amendment with its twenty dollar justice clause, then what are Caesar’s things?

Certainly, constitutional law, our Caesar and temporal power, is legitimated when followed (see John Locke); just as certainly, it is delegitimated when ignored (see current polity).

We the People matter.

Next Up: The Union 2016 summer series continues on Sunday 17 July with part 5, Johnny Reb and Gus Kotka Nowhere Feather Birds.

Posted by Bryan W. Brickner

Summer Union 2016: Johnny Reb and Gus Kotka Nowhere Enemy Is Time

7/11/2016

Johnny Reb and Gus Kotka Nowhere Enemy

Part 4 of 13

“I figured Tory Crown for an …” Gus hesitated, “you know Reb …”
“An enemy.”
“That.”
“Tory can be For and/or Against Gus.”
“For and/or Against what?”
“Constitution.”
“Republic.”

Johnny Reb and Gus Kotka Nowhere Is

“Same thing.”
“Agreed.”
“During the war,” Reb continued, “Tory Crown mostly supported the Confederacy.”
“Anti-republic.”
“Yes.”
“And by mostly you mean Tory Crown was in the North too?”
“You mean were there Yankee Tory Crowns?”
“Yes.”
“There were.”
“Anti-republic goals posing -”

Johnny Reb and Gus Kotka Nowhere Time

“And passing.”
“- Okay, posing and passing as republican goals.”
“That is true Gus.”
“So Tory Crown is fundamental because of power.”
“True again Yank.”
“That’s why in war Tory Crown bets on both sides.”
“You think well Gus.”
“Thanks Johnny,” Gus noted and suggested, “shall we take a closer look?”
“Lean-in perhaps?”
“Yes.”
“Let’s.”

Next Up: Part Two of the 7/20 Bill of Rights Participation Day Preparations, Jesus and Caesar, Friday July 15th.

Posted by Bryan W. Brickner

2020: Bivalent Ligands Targeting Cannabinoid Receptors? Longer Linkers May Not Be The Solution

7/9/2016

CNR1 is CB1 genetics

CB1 pharmacophore

Today’s cannabinoid system science update looks at a piece of pharmaceutical research on bivalency and our CB1 receptors. Pharmaceutical researchers are trying to duplicate the cannabinoid bivalency trait found in our bodies, which is the ability to simultaneously influence two different kinds of receptors.

They understand what our bodies do (“evidence suggests that ligands enter CB1 through the lipid bilayer”) yet don’t know how to copy it (“linkers are unlikely to exit the receptor through its external face”). They conclude: “the entire premise of designing bivalent ligands targeting CB1 must be revisited.”

Our bodies keep doing the bivalency shuffle, all the time and every day, while the pharmaceutical researchers revisit the drawing board, and maybe (perhaps) take Nixon’s scheduling law with them.

Trends in Pharmacological Sciences
PubMed 2016
One for the Price of Two…Are Bivalent Ligands Targeting Cannabinoid Receptor Dimers Capable of Simultaneously Binding to both Receptors?

Abstract:
Bivalent ligands bridging two G-protein-coupled receptors (GPCRs) provide valuable pharmacological tools to target oligomers. The success of therapeutically targeting the cannabinoid CB1 receptor has been limited, in part due to its widespread neuronal distribution. Therefore, CB1 ligands targeting oligomers that exhibit restricted distribution or altered pharmacology are highly desirable, and several bivalent ligands containing a CB1 pharmacophore have been reported. Bivalent ligand action presumes that the ligand simultaneously binds to both receptors within the dimeric complex. However, based on the current understanding of CB1 ligand binding, existing bivalent ligands are too short to bind both receptors simultaneously. However, ligands with longer linkers may not be the solution, because evidence suggests that ligands enter CB1 through the lipid bilayer and, thus, linkers are unlikely to exit the receptor through its external face. Thus, the entire premise of designing bivalent ligands targeting CB1 must be revisited.

Next Up: The Union 2016 summer series continues on Sunday 10 July with part 4, Johnny Reb and Gus Kotka Nowhere Enemy Is Time.

Posted by Bryan W. Brickner

Summer Union 2016: Johnny Reb and Gus Kotka Nowhere Know Sympathy

7/3/2016

Johnny Reb and Gus Kotka Nowhere Know

Part 3 of 13

“Us you say.”
“Right.”
“What makes you think balancer Johnny?”
“Crown being around.”
“Means?”
“Well,” Reb reflected, “Crown never stands alone Gus.”
“Needs a realm.”
“Needs people.”
“So if Crown’s around …”

Johnny Reb and Gus Kotka Nowhere Sym

“Morgan’s around.”
“The Teamster?”
“Right.”
“That takes me back Reb.”
“It should.”
“We were talking representation and free people,” Gus pondered, “and it was Juneteenth.”
“It was.”
“What’s the balancer though? That’s not Daniel Morgan in the sunflowers.”
“Something different.”

Johnny Reb and Gus Kotka Nowhere Pathy

“You seem confident Reb, I mean, you’re not hatin' on Tory Crown.”
“Hate is a pathos Gus.”
“A disease.”
“Yes.”
“And Crown knows that?”
“Yes.”
“So the balance involves Crown Johnny?”
“Crown’s fundamental Gus.”

Next Up: 8 July and a 2020: Bivalent Ligands Targeting Cannabinoid Receptors? Longer Linkers May Not Be The Solution

Posted by Bryan W. Brickner

2020: Part One of the 7/20 Bill of Rights Participation Day Preparations, 20 Minutes for Twenty Dollars

7/1/2016

US Constitution, Amendment VII

Working on some numbers showing We the People as a collective power. Basically, I got to wondering what could happen if we all did something for 20 minutes for the “twenty dollars” in Amendment VII; sort of a what if there was a Participation Day for the 7th Amendment and its twenty dollar clause? What would that equal as participation time?

Let’s view it as a story problem.

Estimating, we can use 300 million US citizens acting for 20 minutes, so that is 1/3 of an hour and equals 100 million hours.

Take 100 million hours divided by 25-hour days (easy math) and you get four million days.

Take four million days divided by 400-day years (more easy math) and the answer is 10,000 years.

So Americans spending 20 minutes writing a letter or sending an email or talking with a friend on July 20th (or any convenient time) in support of the US Constitution and the twenty dollar clause in the 7th Amendment of the Bill of Rights, would be equivalent to 10,000 years of participation in one effort.

We the People is definitely a collective power.

Part Two of the 7/20 Bill of Rights Participation Day Preparations, Jesus and Caesar, will be posted 15 July.

Next Up: The Union 2016 summer series continues on Sunday 3 July with Johnny Reb and Gus Kotka, Nowhere Know Sympathy.

Posted by Bryan W. Brickner