Think of a cell as a hub: a center of communication.
This hub has gates and points of entry: for our example, think of cannabinoid and progesterone receptors. These receptors facilitate communication with other hubs and inside a hub (with other cells and inside a cell).
There are nuclear receptors in all hubs/cells; these receptors regulate our genes (by transcribing DNA) and control our development, homeostasis and metabolism.
Recall that endometriosis is a disruption of a hub and its network: the cells grow (generate) as they are designed to do, just in the wrong spot.
An obvious point of disruption and research is the communication between progesterone and nuclear receptors; another is anandamide and all the other cannabinoids (endo, plant and pharmaceutical), as they too can modulate nuclear receptors.
We’ll begin with that homeostatic science next week: cannabinoids modulating nuclear receptors - and thus our every day.
*Next Up: Wednesday 7 June and a Homeostasis: If Not CB Three, then CB Third.
Posted by Bryan W. Brickner